The mRNA Vaccines Bias The Immune System In Favor Of Creating Tolerance To High Virus Load - Rather Than Initiating An Immune Response Which Gets Rid Of The Virus
And this has consequences (as seen below), in prolonged infections, resultant organ damage, and the possibility of getting repeat infections with the SARS-CoV-2 virus, as well as other viruses...
OK, here’s the case in point:
”Willie Nelson gives a thumbs-up after receiving COVID-19 vaccine … "Take care of yourself and others," he urged his followers. January 15, 2021, https://abcnews.go.com/GMA/Culture/willie-nelson-thumbs-receiving-covid-19-vaccine/story”
And so a year and a half later, he comes down with COVID, something you would not expect with a vaccine that provides immunity, like the Tdap/MMR or TB vaccines. Instead, we get this: “Like most people moving through the last few years, Nelson and his loved ones worked hard to avoid contracting COVID-19 since the pandemic hit in 2020. The illness has killed millions all across the globe, and the 89-year-old singer would be considered to be in a high-risk group when it comes to the virus.
Willie Nelson, however, wasn’t able to fend the virus off completely it seems, as the On the Road Again singer contracted the illness in May. However, fans did not learn how life-threatening this bout was for the singer until months later.
“There were a couple of times when I wasn’t sure he was going to make it,” Willie Nelson’s son Lukas said in a conversation with New York Times Magazine . According to reports, Willie Nelson was facing challenges walking or talking as he battled the illness. Thankfully, however, the superstar found respite in singing and playing the guitar. These activities got him through the most difficult times, the reports note.
https://www.newsbreak.com/news/2872011370306/willie-nelson-enjoys-christmas-with-family-following-life-threatening-health-scare”
So instead of a proper immune response, which is what you get from IgG3, he got a prolonged bout of the sickness which nearly killed him - the virus was allowed to replicate seemingly without limit without producing severe symptoms - and perhaps with Willie, he came close to a tipping point. OK, here’s why:
”What Does Immune Tolerance Do?
Immune tolerance prevents rapid clearance of the infection, making boosted people the slowest to clear Covid-19.
It prevents the formation of lasting neutralizing immunity, thus making affected people suffer from repeat reinfections. In other words, forget herd immunity.
The utter absence of herd immunity can be seen in this Santa Clara County, California chart of Sars-Cov-2 in wastewater:
Rintrah shows the same type of picture for his highly-vaccinated motherland Netherlands:
Immune Tolerance is a Biological Time Bomb
Could repeat Covid infections, caused by immune tolerance, lead to increased mortality? Absolutely! This Singapore study suggests that most excess deaths in Singapore happen within 90 days of a Covid infection. A lot of such deaths, unfortunately, are not recorded as Covid deaths. They could be recorded as “sudden deaths” from “unknown cause.”
The disease may seem mild if immune tolerance fails to elicit a strong reaction and stop viral replication. The virus, proliferating unopposed, damages the cardiovascular system more than in those who can mount a vigorous immune reaction. One such victim is Gwen Casten, a 17-year-old daughter of vaccine-loving congressman Sean Casten. Gwen died suddenly in her sleep in June of 2022 after suffering a “very mild” Covid infection.
It takes time for immune tolerance to develop after boosting. As the Immunology article says:
These three individuals experienced the infection with the largest time difference to the last vaccination, at 95, 201 or 257 days after the second vaccination, while in the other nine patients the infection took place between 25 and 78 days after the second mRNA shot. This supports the hypothesis that the switch to IgG4 is a consequence of ongoing GC maturation and that it takes several months until IgG4-switched memory B cells appear.
This “taking months to develop” is a biological time bomb placed into the immune systems of boosted people! It takes the germinal centers months after the third injection to switch to the useless IgG4.
Therefore, many months after the booster dose, a Covid infection is met with worthless, forgiving, and disease-ignoring IgG4 antibodies. The infection seems mild; the virus replicates unopposed due to the IgG4 switch; the cardiovascular system is damaged; the risk of sudden death multiplies!”
So you may be vaccinated and boosted and not really feel much, until you either drop dead or recover after a long and debilitating illness - and you’ll be amongst the first to catch subsequent mutations and go through the same thing all over again. We may need a vaccine for the vaccine…
I’m adding this for Vincent’s edification - and it might clear things up for others. And of course, it has inline references which need to be read:
”On average, the four who had a breakthrough infection after their booster are now at 42.45% IgG4. The cohort as a whole is at 19.27%, up from just 0.04%, so the ones who haven’t had a breakthrough infection yet will end up at a similar position: A response that is entirely IgG4 dominated.
IgG4 isn’t really meant for neutralization. Out of the IgG’s, IgG3 is the excellent virus neutralizer. What IgG3 does in the case of SARS2, is that they have their tails bind together. This means that out of all the four subclasses, IgG3 is showing 50-fold stronger neutralization than the other three subclasses against SARS2.
… Look at what happens to IgG3 after three shots:
There is some IgG3 left in some people after the second shot, but by the time they get the third shot, they’re all universally down to a flat zero.
So, Rintrah explains that the immunology study shows depletion of all-important, virus-fighting IgG3 antibodies and their replacement (class switch) with useless IgG4 antibodies. Those turn Covid infection to be needlessly “mild” but fail to clear the virus promptly.
We have fevers for a reason!
Again, if you have not read Rintrah’s article and have spare 30 minutes, take a look.
Other Discussions of IgG4 and Immune Tolerance
I mentioned immune tolerance last June, referring to a surprisingly lucid Internet prediction from Sep 2021 (archive link) that was coming true epidemiologically:
The famous science substacker Brian Mowrey posted a great post last July. He introduces us to IgG4 and immune tolerance and gives us a great introduction:
I will mention a few of my related posts in the links below.
What Does Immune Tolerance Do?
Immune tolerance prevents rapid clearance of the infection, making boosted people the slowest to clear Covid-19.
It prevents the formation of lasting neutralizing immunity, thus making affected people suffer from repeat reinfections. In other words, forget herd immunity.”
…
Are you intentionally trying to mislead people. The New England Journal of Medicine correspondents article this seems to be based on specifically states in their findings.
“ There were no appreciable between-group differences in the time to PCR conversion or culture conversion according to vaccination status”
Or are you trying to communicate some other conclusion?