6 Comments

Are you intentionally trying to mislead people. The New England Journal of Medicine correspondents article this seems to be based on specifically states in their findings.

“ There were no appreciable between-group differences in the time to PCR conversion or culture conversion according to vaccination status”

Or are you trying to communicate some other conclusion?

Expand full comment
author
Dec 29, 2022·edited Dec 29, 2022Author

Look at charts D and E here: https://www.nejm.org/doi/full/10.1056/NEJMc2202092, note that we don't see time elapsed since vax or booster, apparently for immune tolerance - the preponderance of IgG4 response as compared to IgG3 - it takes 120 days more or less for that to set in. And "appreciable" is in the eye of the beholder, only in a very few areas were the results not appreciably different - i.e. essentially the same - a superimposed line segment on a graph for example. In any case, the performance for the vaccines should be at least equivalent to natural immunity - and should frankly be better by two or three days, and in most cases the performance is worse, including some percentage of cases where the vaccinated experienced very slow drop in virus load, indicating partial vax failure

Expand full comment
author

We also don't see cycle count or what primers were used - while delta varies by about 10 base pairs from wild type, omicron varies by about 40, so if they're using wild type primers, they may not catch all of the omicron cases.

Expand full comment

If you read the supplementary appendix, you could acquire such information.

If you want to argue that the paper didn’t have much statistical power they plainly say that in the paper. Coming to a conclusion which is contrary to the paper based on the paper seems nonsensical.

Expand full comment

Where in the paper do you find information on IgG3 or IgG4?

Your siding up a correspondence to the editor as evidence, and then contradicting the findings of that paper?

Did you look at the hazard ratio confidence intervals? Do you think they did the math wrong or something? I don’t understand how you come to a different conclusions with those numbers?

Expand full comment
author
Dec 30, 2022·edited Dec 30, 2022Author

I know it's a lot of work, but you have to read the references, i.e. https://igorchudov.substack.com/p/booster-caused-immune-tolerance-explains - and I appended an excerpt from this paper, too.

Expand full comment